The Molecular Biology, HLA Immunology and Virology Diagnostic Laboratory was founded in 2000 by Mr. Professor Doctor Ioanel Sinescu, Director of the Center for Urological Surgery, Dialysis and Renal Transplantation of the Fundeni Clinical Institute. We mention that it is the first molecular biology laboratory in transplant immunology in Romania. This laboratory was accredited by the European Federation of Immunogenetics in 2006. (see accreditation certificate)
Since 2006, the Laboratory has changed its name to the Center for Immunogenetics and Virology and is a Reference Center in Transplant Immunology in Romania, a methodological forum, periodically organizing workshops, round tables and courses in the field of histocompatibility, immunogenetics and virology, congresses and other national and international scientific events.
Presentation of the Medical Analysis Laboratory 2 (LAM 2)
DIAGNOSTICS MOLECULAR BIOLOGY
IMMUNOLOGY HLA and VIRUSOLOGY
The Medical Analysis Laboratory 2 was founded in 2000 by Mr. Academician, Professor Doctor Ioanel Sinescu, Director of the Center for Urological Surgery, Dialysis and Renal Transplantation of the Fundeni Clinical Institute. We mention that it is the first functional, molecular biology laboratory in transplant immunology in Romania. This laboratory was accredited by the European Federation of Immunogenetics (EFI) in 2006. (see accreditation certificates)
Since 2006, the laboratory has been a Reference Center in Transplant Immunology in Romania, a methodological forum, periodically organizing international workshops, round tables and courses in the field of histocompatibility, immunogenetics and virology, congresses and other national and international scientific events.
The main activity of the laboratory consists in carrying out all the necessary virological and immunological investigations in order to perform a transplant, either of a solid organ (kidney, heart, liver, lung, etc.), or of hematopoietic stem cells.
These investigations are performed both on recipients of a transplant and on donors (living or brain dead) and include: indirect virological diagnosis (viral screening) and direct diagnosis (determination of viral load) for hepatitis viruses (A, B, C, D), HIV , herpesviruses (CMV, EBV), parvovirus B19, BK polyomavirus, adenoviruses, HTLV, toxoplasma gondii; tumor markers (AFP, CEA, CA 19-9, CA 125, CA 15-3, total and free PSA, Cyfra 21-1); screening and identification of anti-HLA antibodies; low, medium and high resolution HLA genotyping, establishing recipient-donor compatibility; the crossmatch test; Chimerism monitoring in bone marrow transplantation.
At the same time, the Medical Analysis Laboratory II provides the necessary investigations for the monitoring of recipients in the post-transplant period: the evaluation of viral infections and tumor markers in the context of immunosuppressive treatment; rejection immunology (anti HLA antibodies); dosage of immunosuppressive treatment (cyclosporine, tacrolimus, sirolimus).
For the other sections of the Fundeni Clinical Institute, which do not carry out transplant activity, the laboratory performs direct and indirect virological diagnostic tests, tumor markers, specific HLA genotyping, associated with certain diseases (HLA B27, HLA DQ).
Also, the Center for Immunogenetics is involved in the activity of coordination and virological and immunological testing for the National Register of Voluntary Donors of Hematopoietic Stem Cells.
In parallel, the members of the laboratory act as members of the Carol Davila University of Medicine and Pharmacy in Bucharest, coordinating the Immunology and Transplant Immunology Discipline for the Romanian language module and the English language module.
Center for Immunogenetics and Virology Fundeni
Medical Analysis Laboratory 2 (LAM 2)
LAM 2 is the first molecular biology laboratory in transplant immunology in Romania, being accredited by the European Federation of Immunogenetics (EFI) in 2006.
Since 2006, the laboratory has been a Reference Center in Transplant Immunology in Romania, a methodological forum, periodically organizing international workshops, round tables and courses in the field of histocompatibility, immunogenetics and virology, congresses and other national and international scientific events.
The main activity of the Center for Immunogenetics and Virology consists in performing all the necessary virological and immunological investigations in order to perform a transplant, either of a solid organ (kidney, heart, liver, lung, etc.), or of hematopoietic stem cells.
These investigations are performed both on transplant recipients and donors (living or brain dead) and include: indirect virological diagnosis (serological screening) and direct diagnosis (determination of viral load) for hepatitis viruses (A, B, C, D), HIV , herpesviruses (CMV, EBV), parvovirus B19, BK polyomavirus, adenoviruses, HTLV, toxoplasma gondii; tumor markers (AFP, CEA, CA 19-9, CA 125, CA 15-3, total and free PSA, Cyfra 21-1); screening and identification of cytotoxic antibodies; HLA genotyping and establishing recipient-donor compatibility; crossmatch test; Chimerism;
At the same time, the Center for Immunogenetics and Virology provides the necessary investigations for the monitoring of recipients in the post-transplant period: the evaluation of viral infections and tumor markers in the context of immunosuppressive treatment; immunological rejection (anti-HLA antibodies); dosage of blood levels of immunosuppressants (cyclosporine, tacrolimus, sirolimus);
For the other sections of the Fundeni Clinical Institute, which do not carry out transplant activity, the laboratory performs direct and indirect virological diagnostic tests, tumor markers, specific HLA genotyping, associated with certain diseases (HLA B27, HLA DQ). Also, the Immunogenetics Center is involved in the activity of coordination, recruitment, donation and virological and immunological testing for the National Register of Voluntary Donors of Hematopoietic Stem Cells.
In parallel, the members of the laboratory act as members of the Carol Davila University of Medicine and Pharmacy in Bucharest, coordinating the Immunology and Transplant Immunology Discipline for the Romanian language module and the English language module.
